Unfortunately, Taixing used “TD” for the Chinese word tidai, meaning “substitute”. Synonyms and Related Terms. Packaging 1, 4 L in poly bottle 18 L in steel drum Legal Information Product of Dow Chemical What is Diethylene Glycol Monobutyl Ether? 14th ed. From CAMEO. Only approximately 3,000 bottles had been analyzed from the total 6,000 bottles collected. diethylene glycol monobutyl ether acetate of 200 or 2000 mg/kg body weight, male Sprague Dawley rats exhaled about 5% of the administered radioactive dose as 14CO 2. The children later developed kidney failure and died. [35] By June 1996, with no idea what was causing the epidemic, the Pan American Health Organization (PAHO) Haiti representative contacted the World Health Organization (WHO, the parent agency of PAHO), and WHO requested that the Centers for Disease Control and Prevention investigate.[36][29][37]. [38], Ending June 1996, the FDA had discovered counterfeit glycerin traced back to Chemical Trading and Consulting (a German broker), which bought 72 barrels of the syrup from Vos B.V., a Dutch company. This page was last edited on 28 November 2020, at 22:06. Soon thereafter, patients died after receiving the medication. Once he was inside, there was nothing to do: the plant had already been shut down. One year and a half after the FDA began to trace the poisonous shipments, an inspector, Ted Sze, finally visited the Tianhong Fine Chemicals Factory in Dalian, northeastern China. 3053. Despite the discovery of DEG’s toxicity in 1937 and its involvement in mass poisonings around the world, the information available regarding human toxicity is limited. [1][7], At first, scientists thought that DEG metabolized into ethylene glycol, which is poisonous due to the metabolic production of glycolic acid, glyoxylic acid, and ultimately oxalic acid. Only 88 children deaths were recalled by doctors or had medical records. 45 Austrian, 5 German and 12 Italian wines tested positive for DEG. Vos records revealed the syrup had been bought from Sinochem International Chemicals Company through a German trader, Metall-Chemie. Bogdanich, W.; McLean, R. "Poisoned Toothpaste in Panama Is Believed to Be From China". English: Structure of Diethylene glycol monobutyl ether acetate. Industry Circular No. Incidents include its use in China as a component of cheap toothpaste, and by winemakers in Europe as an adulterant to create a "sweet" wine. [1][7], The symptoms of poisoning typically occur in three characteristic intervals:[1], Fomepizole or ethanol should be quickly administered to prevent diethylene glycol being metabolized to the compound or compounds that cause the real damage.[1]. Doctors had no idea what was happening: the mysterious illness was attacking elderly citizens with hypertension and diabetes history. Bogdanich, W. "Toxic Toothpaste Made in China Is Found in U.S. ". Diethylene glycol monobutyl ether. CS1 maint: multiple names: authors list (. [5] DEG is used as a building block in organic synthesis, e.g. Shortly after, 2-hydroxyethoxyacetaldehyde (C4H8O3) is metabolized by the enzyme aldehyde dehydrogenase (ALDH) into the weak acid 2-hydroxyethoxyacetic acid (HEAA) with chemical formula C4H8O4. [20], In Cape Town, South Africa, seven children developed vomiting, diarrhea, and dehydration, and died of kidney failure after administration of over-the-counter sedatives. With the available technology of the era, the CDC determined the glycerin used in the syrup preparation was contaminated with approximately 24% DEG. Panamanian officials traced the toothpaste to a local company in the Colón Free Trade Zone. Reuter. Authorities warn against using some toothpastes, Taste of Raspberries, Taste of Death – The 1937 Elixir Sulfanilamide Incident, "Wallace Reveals How Federal Agents Traced Elixir to Halt Fatalities", "Medication-associated diethylene glycol mass poisoning: A review and discussion on the origin of contamination", "Popular Wines found to hold toxic chemical. Promotes uniform dispersion; translucent to clear. They react with oxoacids and carboxylic acids to … Records also revealed that to fool buyers, Wang falsified his license and laboratory analysis reports. [62][63], The Nigerian government traced the diethylene glycol to an unlicensed chemical dealer in Lagos, who sold it to a local pharmaceutical manufacturer. [1][7], Based on available literature, scientists suggest unmetabolized DEG and HEAA are partially reabsorbed through glomerular filtration. It appears diethylene glycol is more hazardous to humans than implied by oral toxicity data in laboratory animals.[1]. of morpholine and 1,4-dioxane. [3], "Diethylene glycol is derived as a co-product with ethylene glycol (MEG) and triethylene glycol. Butyl di glycol (also known as BDG, butyl dioxitol, diethylene glycol monobutyl ether, 2(-2butoxyethoxy) ethanol and butoxydiethylene glycol) is a colourless, clear organic compound with a faint characteristic odour that has the formula C 8 H 18 O 3.It is soluble in water and miscible with many common solvents, and also has low volatility and a high boiling point. About half were receiving Lisinopril (a blood pressure medicine), and many did not remember clearly if they had been taking other drugs. Some wines contained less than 10 parts per million of DEG, a small amount that could not be detected by laboratory analysis in Europe. It is also used in printing inks when very slow drying is desired. diethylene glycol monobutyl ether (English) retrieved. It was not until September 1996 that Sinochem provided a name of the manufacturer of the tainted syrup. [2] It can be a contaminant in consumer products; this has resulted in numerous epidemics of poisoning since the early 20th century. Description. [39][41], Taixing sold the syrup as “TD glycerin”, wording that neither Chinese inspectors nor Spanish medical authorities comprehended. • As a cosurfactant in the formation of microemulsions. Later, raw glycerin was analyzed and results revealed 22.2% v/v DEG. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. For late diagnosis where ethanol or fomepizole is ineffective, because DEG has already been metabolized, hemodialysis becomes the only treatment available. Diethylene glycol, monobutyl ether Ethyl Digol Glycol Ether DM ETHANOL, 2-(2-ETHOXYETHOXY)-DEGME. Although there is limited information about toxicokinetics in humans, observations in mass poisonings and experimental studies suggest the following information: The principal method of absorption is through oral ingestion. DEG is a widely used solvent. [52], On June 1, 2007, the FDA warned consumers to avoid toothpaste from China, although there was no information if these toothpastes had already entered the US, and started testing any imported Chinese toothpaste. 0 references. [23][24][25], After recalling millions of wine bottles, the Austrian Government had no idea how to destroy the product. Ethylene glycol is by far the largest volume of the glycol products in a variety of applications. Bogdanich, W. "Wider Sale Is Seen for Toothpaste Tainted in China ", U.S. Bureau of Alcohol, Tobacco and Firearms, Centers for Disease Control and Prevention, "Toxic alcohol ingestions: clinical features, diagnosis, and management", ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN: Polyethylene glycol, Existing Chemical Hazard Assessment Report, Australian Competition and Consumer Commission, "Toothpaste containing more than 0.25 per cent by weight of diethylene glycol (DEG)". DIETHYLENE GLYCOL MONOBUTYL ETHER is a ether-alcohol derivative. BlmSchV (Hazardous Incident Ordinance) [1][19][29][30], In Bangladesh between 1990 and 1992, 339 children developed kidney failure, and most of them died, after being given paracetamol (acetaminophen) syrup contaminated with diethylene glycol. The toothpaste was labeled as “Manufactured in South Africa” and contained misspellings like "isclinically", "SOUTH AFRLCA" and "South African Dental Assoxiation". The death rate of this mysterious illness was nearly 50%, when hospital management decided to isolate all the patients with the illness in a large room and doctors could compare notes and theories. Whitehouse Station, NJ: Merck & Co; 2006. [67] On 9 January 2020, a police report indicated quantities of diethylene glycol in one brand of beer from a small upscale brewery that could have poisoned 18 people in Belo Horizonte and other cities in Minas Gerais state. I, the copyright holder of this work, hereby publish it under the following licenses: All structured data from the main, Property, Lexeme, and EntitySchema namespaces is available under the. It is supplied as a urethane grade solvent. Diethylene glycol monobutyl ether is used as a solvent in paints and varnishes e.g. It is a solvent for nitrocellulose, resins, dyes, oils, and other organic compounds. 17 November 2016. Once physicians identified a suspect paracetamol syrup, samples were shipped to the Centers for Disease Control and Prevention (CDC) in the U.S., which identified DEG. The poison had caused the death of at least 84 Nigerian children between ages of two months and seven years. Massengill Co. (a Tennessee drug company), manufactured sulfanilamide dissolved with diethylene glycol, to create a liquid alternative of this drug. About 7% of these are Leather Auxiliary Agents, 47% are Alcohol & Hydroxybenzene & Ether, and 3% are Other Chemicals. They also arrested 12 people in connection with the incident. [3] Because of its adverse effects on humans, diethylene glycol is not allowed for use in food and drugs. diethylene glycol monobutyl ether (English) retrieved. A series of solvents used for oils, resins, gums and many polymers that is sold commercially under the name Carbitol. Glycols related to and coproduced with diethylene glycol and have the formula HOCH2CH2(OCH2CH2)nOH are: These compounds are all hydrophilic, more so than most diols, by virtue of the ether functionality. It was assumed that DEG was used as a substitute of propylene glycol, and this incident encouraged the Nigerian government to develop pharmaceutical quality control guidelines. Patients were treated with fluid hydration and correction of acidosis, but some were not able to survive. Jean-Claude Bradley Open Melting Point Dataset, NFPA 704: Standard System for the Identification of the Hazards of Materials for Emergency Response, InChI=1S/C8H18O3/c1-2-3-5-10-7-8-11-6-4-9/h9H,2-8H2,1H3, Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard, splash10-006t-9000000000-9b5ce4bf5bfa84239e88, splash10-03di-1900000000-8aef03e0bb456b96d1a4, splash10-03di-0900000000-3ac8a328666dee650638, splash10-0a4j-9000000000-44b0731c3639435643fb, https://www.wikidata.org/w/index.php?title=Q1018210&oldid=1314798026, Creative Commons Attribution-ShareAlike License. Features. The product was recalled and after an investigation, the Drug Controller General of India, VG Somani, said at India Pharma 2020, that the GMP was not followed, and negligence was found during the production process itself. It is used primarily as a coalescing aid in latex paints and as a solvent in printing inks. Diethylene Glycol Monobutyl Ether poisoning symptoms, causes, diagnosis, and treatment information for Diethylene Glycol Monobutyl Ether poisoning (Chemical poisoning - Diethylene Glycol Monobutyl Ether) with alternative diagnoses, full-text book chapters, misdiagnosis, research … Austrian wine was banned in many countries and the U.S. Bureau of Alcohol, Tobacco and Firearms started to test all imported wine. [11] The major cause of ethylene glycol toxicity is the accumulation of glycolic acid in the body,[12] but the accumulation of calcium oxalate crystals in the kidneys can also lead to acute kidney failure. The OEL or MAK value for diethylene glycol monobutyl ether is 67 mg/m 3 (10 ppm) [1, 2]. These measures quickly ended the advance of the epidemic. When 105 people died in 15 states during the months of September and October, the trail led back to the elixir, and the toxic potential of this chemical was revealed. The prognosis depends on prompt diagnosis and treatment due to the high mortality rate DEG intoxication produces. They react with oxoacids and carboxylic acids to … [29], The Panamanian Government made a nationwide campaign, collecting around 6,000 bottles of cough syrup and three other products with the tainted glycerin manufactured by Social Security Laboratories. The ether being relatively unreactive. Some time later, Wang found a reference to diethylene glycol in a chemical book. The company tested the new product, Elixir Sulfanilamide, for viscosity, appearance and fragrance. During September 1986, the Ministry of Public Works started testing a mixture of wine with salt to melt hazardous ice during winter. In July 1996, the American Embassy in China contacted Sinochem and requested a list of Chinese glycerin makers, but the company refused to reveal the names. At the time, the food and drug laws did not require toxicological analysis before releasing for sale. UNII. The risk assessment is based mainly on open scientific literature and on skin absorptions studies done by Industry. [1] In personal care products (e.g. The Himachal Pradesh government is filing a criminal case against the company and its executives. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. [3] Meanwhile, in Panama, De la Cruz, legal representative of Medicom, remains in jail pending a trial. Soon, patients from other parts of the country started to arrive at hospitals. [39], Ending September 2006, the Arnulfo Arias Madrid Hospital at Panama City was getting full with patients with contradictory symptoms. High boiling point. Siegfried Rebsdat and Dieter Mayer "Ethylene Glycol" in Ullmann’s Encyclopedia of Industrial Chemistry, 2002, Wiley-VCH, Weinheim. Mr. Wang was caught and Qiquihar was shut down by the authorities. The LD50 for small mammals has been tested at between 2 and 25 g/kg, less toxic than its relative ethylene glycol, but still capable of causing toxicity in humans. This triggered the installation of more sensitive laboratory equipment in Banafi laboratories, Italy, and stronger alcohol regulations in Austria. The counterfeit syrup ended in ampules of Amillarisin A, a medication for gall bladder problems; special pediatric enema fluid; blood vessel disease injections; intravenous pain reliever; and an arthritis medication. DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Candidate List DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Annex XIV List 15.1.2. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. An unmitigated tragedy", "Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. In fact, Rasfer received the product from CNSC Fortune Way, which in turn bought it from the Taixing Glycerine Factory. "FDA Advises Consumers to Avoid Toothpaste From China Containing Harmful Chemical. Diethylene glycol monobutyl ether (DEGBE) is used: • In the preparation of blocked isocyanate systems for coil coating, electro-coating and powder coating. At the request of the United States, the State Food and Drug Administration of China investigated Taixing Glycerine Factory and CNSC Fortune Way, but the agency concluded it is not under their jurisdiction because the factory is not certified to make medicine. Fill out the form below and we will be in touch shortly. [29], When a patient admitted for a heart attack developed the mysterious illness at the hospital, Dr. Nestor Sosa, an infectious disease specialist, analyzed the medical record. Acute Renal Failure Investigation Team", "Fatal renal failure caused by diethylene glycol in paracetamol elixir: the Bangladesh epidemic", "Identification and Quantification of Diethylene Glycol in Pharmaceuticals Implicated in Poisoning Epidemics: An Historical Laboratory Perspective", "F.D.A. [31], A propolis syrup manufactured by Huilen Laboratories in Buenos Aires, Argentina, contained between 24 and 66.5% DEG, and caused the death of 29 people. [19] This law, though extensively amended in subsequent years, remains the central foundation of FDA regulatory authority to the present day. [55][56] Although there were no reports of anyone harmed, several people in the eastern US reported experiencing headaches and pain after using the product. CAS Number 111-76-2 Synonym(s) EGBE, AI-0993; Bucs; Butoxyethanol; Beta-butoxyethanol; 2-Butoxyethanol; 2-butoxy-1-ethanol; Butyl cellosolve; o-butyl ethylene glycol; Butyl glycol; Butyl oxitol; Caswell No. Details : Ethylene Glycol Monobutyl Ether. Internal Medicine Residency Program of the College of Medicine of Wake Forest University, North Caroline, U.S.A. 121; Ethylne glycol butyl ether; Ethylene glycol monobutyl ether; Glycol butyl ether; Monobutyl glycol ether; 3-oxa-1-heptanol; EPA Pesticide Code: 011501 The agency also identified urinary DEG as a biomarker for DEG exposures. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. The ether being relatively unreactive. Date: 27 January 2011: Source: Own work: Author: MiPe: Licensing . [60] The world outcry made Chinese officials ban the practice of using diethylene glycol in toothpaste. [61], Ending November 2008, infants started to die after developing unexplained fevers and vomiting. DIETHYLENE GLYCOL MONOBUTYL ETHER 9TB90IYC0E Overview Structure Names 10: Classification 1: Identifiers 9: Relationships 1: Active Moiety 1: Audit Info References 15: Moieties 1: Substance Class: Chemical Record UNII: 9TB90IYC0E. Testing of medication samples taken from the factory samples by both CDC and by an independent commercial lab located in Miami, revealed contamination by DEG of 16.4% and higher. About Diethyl Glycol Monobutyl Ether Enquire Now. The regional drug controller authorities after investigation found out that a faulty batch of the Coldbest PC cough syrup contained 34.97% of diethylene glycol, which resulted in poisoning and subsequent renal failures. [32][33][34], In the poorest country in the Western Hemisphere, disease outbreaks are not recognized unless widespread or unusual. It is a clear liquid with a very low odor and high boiling point. The resulting product is two ethylene glycol molecules joined by an ether bond. FDA Detains One Contaminated Shipment, Issues Import Alert", June 1, 2007. BACKGROUND A risk assessment of DEGBE with the chemical name 2-(2-butoxyethoxy)ethanol or diethylene glycol monobutyl ether was done by a member state (France). [70] The investigation revealed that DEG had been used as a coolant for the brewery equipment, in what should have been a closed circuit, but an undetected leak in the system contaminated some batches of beer. U.S. Food and Drug Administration Press Release. [10], Diethylene glycol has moderate acute toxicity in animal experiments. Hemodialysis might be administered alone or with ethanol or fomepizole. [68][69] On 9 June, the police indicted 11 people, including brewery owners and employees, for manslaughter, unintentional bodily harm and food contamination. It can also serve as a dispersant in organosols and can also be used in preparation of plasticizers. AICS Chemical ID. The primary results revealed that the mixture was more effective than using salt alone. Record Status: Validated (UNII) … A wide variety of diethylene glycol monobutyl ether options are available to you, such as classification, grade standard, and usage. [42], In August 2009, the Supreme Court decided to send the diethylene glycol file to the Public Ministry for an extension. * * In April 2006, the Guangdong Province Hospital of Guangzhou began administering Amillarisin A to their patients. 9TB90IYC0E. [45] Spanish authorities are prosecuting Asunción Criado, general manager of Rasfer Internacional, S.A., and await Panamanian citizens, René Luciani (former Social Security Director) and Jéssica Rodríguez (former Purchase National Director) for their hearings. Dermal absorption is very low, unless it is administered on broken or damaged skin. National regulations Germany 12th Ordinance Implementing the Federal Immission Control Act - 12.BImSchV: Is not subject of the 12. [42] In Spain, Rasfer International declared bankruptcy after the lawyer of Medicom filed a lawsuit of $400 million in July 2008. Investigations revealed that all had taken a medicine called “My Pikin Baby”, a teething mixture tainted with diethylene glycol. [44], The New York Times reported that Taixing was closed by the Chinese government and CNSC Fortune Way, which is also owned by the Chinese government, was never sanctioned. [53][54] Days later, Colgate-Palmolive found counterfeit toothpaste with its name, which was contaminated with DEG and found at dollar-type discount stores in New York, New Jersey, Pennsylvania and Maryland. Diethyl Glycol Monobutyl Ether. The factory of the medication manufacturer, Pharval, was subsequently investigated by Dr. Joel Selanikio (also of CDC, and an Epidemic Intelligence Service classmate of Katherine O'Brien). [26] The next year, an Austrian electric power plant (Österreichische Draukraftwerke) in Carinthia announced that technicians developed a way to produce energy through burning 30 million liters of contaminated wine. [57] It was later discovered that a great number of tubes with poison ended up in hospitals for the mentally ill, prisons, juvenile detention centers, other hospitals and many other state institutions. This product is created when ethylene oxide and n-butanol are combined. More commonly known as Diethylene Glycol Monoethyl Ether. [1], DEG is produced by the partial hydrolysis of ethylene oxide. [16][17][18] This episode was the impetus for the Federal Food, Drug, and Cosmetic Act of 1938. [11] In the case of DEG, observations demonstrated there were no calcium oxalate crystal deposits in the kidneys, implying ethylene glycol is not on the DEG metabolic pathway. Diethylene Glycol Monobutyl Ether Acetate Market is a professional and a complete report focusing on primary and secondary drivers, market share, competitor analysis, leading segments and geographical analysis. Some authors suggest the minimum toxic dose is estimated at 0.14 mg/kg of body weight and the lethal dose is between 1.0 and 1.63 g/kg of body weight,[7] while some suggest the LD50 in adults is of ~1 mL/kg,[1] and others suggest this is the LD30. Between November 1995 and June 1996, almost 109 children admitted to the University Hospital in Port-au-Prince, Haiti, presented with acute kidney failure. [1][19], Patients being treated for burns developed sudden anuric kidney failure. "Counterfeit Colgate Toothpaste Found", June 14, 2007. [1][19][28], During the summer months, 47 children were admitted to the Jos University teaching hospital, Nigeria, with anuria, fever and vomiting. Diethylene Glycol Monobutyl Ether Uses: This product is used primarily in the manufacturing of lacquers based on nitrocellulose, cellulose ethers and chlorinated rubber. 86-13. Low vapor pressure. Diethylene Glycol Monobutyl Ether exposure symptoms, causes, diagnosis, and treatment information for Diethylene Glycol Monobutyl Ether exposure (Chemical poisoning - Diethylene Glycol Monobutyl Ether) with alternative diagnoses, full-text book chapters, misdiagnosis, research … 1 reference. Diethylene glycol (DEG) is an organic compound with the formula (HOCH2CH2)2O. It is a humectant for tobacco, cork, printing ink, and glue. Eastman™ DE Acetate (Diethylene Glycol Monoethyl Ether Acetate) is a colorless liquid, soluble in water and miscible in most organic solvents. Following restrictive measures decided by one Member State on the basis of Article 12 of Directive 76/768/EEC regarding the use of diethylene glycol monobutyl ether (DEGBE) and ethylene glycol monobutyl ether (EGBE) in cosmetic products, the SCCP was consulted. Diethylene glycol butyl ether is a high boiling solvent, which can be used in coating industry. Besides Wang, five employees of Qiquihar were prosecuted. Diethylene Glycol Monobutyl Ether (DB Solvent) sold by Eastman is a high boiling glycol ether used in baking enamels to promote increased flow-out and leveling in paint films. Patients who survive but develop kidney failure remain dialysis-dependent. Diethylene Glycol Ether Factory Offer High Grade 99% Butyldiglycol/ Diethylene Glycol Monobutyl Ether Cas 112-34-5 US $2.00-$5.00 / Kilogram 1.0 Kilograms (Min Order) 2 Pharmaceutical in 2005. The fiscal attorney urged affected citizens to approach the Public Ministry to update the official legal file and for further medical analysis. [47], During June 2011, the number of confirmed deaths according to the official list rose to 219 victims [48], In May 2007, a Panamanian named Eduardo Arias discovered a 59-cent toothpaste that was labeled containing DEG. [70] On 18 July, the 10th victim died in a Belo Horizonte hospital, a 65-year-old man who had been hospitalized since December 2019 due to the poisoning. Later on, HEAA leaves the liver through the bloodstream, being partially filtered in the kidneys for elimination. UNII. Bureau of Alcohol, Tobacco, and Firearms. Depending on the conditions, varying amounts of DEG and related glycols are produced. Alibaba.com offers 101 diethylene glycol monobutyl ether products. Reference: 1. [64][65][66], In December 2019, some people in the city of Belo Horizonte, initially all from the same neighbourhood, started having symptoms such as nausea, vomiting, abdominal pain, acute kidney failure, facial nerve paralysis, blurred vision, temporary blindness and sensory changes. [67] On 17 January, the police confirmed the fourth death from symptoms matching DEG poisoning, and DEG contamination had been found in eight brands of beer from the same brewery. After ingestion, DEG is absorbed through the gastrointestinal tract and distributed by the bloodstream throughout the body, reaching peak blood concentrations within 30 to 120 minutes. in textile processing and serves as an intermediary product in the chemical industry. The Dutch authorities assessed a $250,000 fine against Vos B.V., for not alerting anyone when they tested the syrup and found impurities.[38]. 2-(2-Ethoxyethoxy)ethanol (IUPAC) Diethylene Glycol Monoethyl Ether. Seventeen other persons have also been charged related to this incident. • As a structural component of various liquid crystals. Furthermore, it is also found in domestic detergents and brewing chemicals. Soon, patients started to present anuria, acidic breathing, hepatomegaly, and unresponsiveness. A dilute solution of diethylene glycol can also be used as a cryoprotectant; however, ethylene glycol is much more commonly used. This being the second incident involving counterfeit glycerine, it prompted the Nigerian National Agency for Food And Drug Administration and Control (NAFDAC) to adopt zero tolerance for counterfeits. Wang declared that after making the first order of counterfeit syrup, he swallowed some of it. [46], Panama’s case made CDC set standardized methodology for DEG identification, hoping to have more timely response in future events. Diethylene glycol is used in the manufacture of saturated and unsaturated polyester resins, polyurethanes, and plasticizers. This event caused the death of five patients.[3][21][22]. Lead CDC investigator Dr. Katherine O'Brien conducted a case-control investigation, looking for potential clues to the epidemic. [43] The following month, the Toxicology Department of the Institute of Legal Medicine and Forensic Science published a list of 1,155 names whose medicine bottles tested positive for DEG. skin cream and lotions, deodorants), DEG is often replaced by selected diethylene glycol ethers. It can be a contaminant in consumer products; this has resulted in numerous epidemics of poisoning since the early 20th century. Diethylene glycol monobutyl ether (DEGBE) is produced by the reaction of ethylene oxide and n-butanol with an alkalic catalyst. [14][15], In 1937, S.E. When urine analyses for a series of metals, pesticides or their metabolites resulted negative, CDC scientists recalled the Nigeria and Haiti incidents. The episode resulted in the deaths of 21 patients and the discovery of glycerin contaminated with 18.5% v/v of DEG. DIETHYLENE GLYCOL MONOBUTYL ETHER 9TB90IYC0E Overview Structure Names 9: Classification 1: Identifiers 9: Relationships 1: Active Moiety 1: Audit Info References 15: Moieties 1: Substance Class: Chemical Record UNII: 9TB90IYC0E. In November, The New York Times published a wine recall that the Federal Government released after the Bureau of Alcohol, Tobacco and Firearms tested 1,000 bottles. English. Chemical Nomenclature. Fourteen patients received hemodialysis, but the treatment failed. [40] The 46 barrels of syrup were bought by Social Security Laboratories through a Panamanian middleman, Grupo Comercial Medicom, who bought the product from Rasfer Internacional, a Spanish company. Availability of DEG will depend on demand for derivatives of the primary product, ethylene glycol, rather than on DEG market requirements."[4]. All the children had received acetaminophen syrup to treat upper respiratory infections related with malaria. Because patients treated with Lisinopril developed a cough (a common side effect of ACE inhibitors), they were prescribed an expectorant. Of glycerin contaminated with 18.5 % v/v DEG absorptions studies done by industry plant had already been shut down polyester... Ether acetate between ages of two locally produced acetaminophen liquid products (.... Bloodstream, being partially filtered in the deaths of 21 patients and the U.S. Bureau alcohol! Component of various liquid crystals out Tianhong ’ s pharmaceutical supply business and earn diethylene glycol monobutyl ether wiki money Weinheim. Page was last edited on 28 November 2020, at 22:06 dilute solution of diethylene glycol also... Sulfadiazine ointment that contained 7 g/kg of DEG and related glycols are produced quickly! 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Contained approximately 8 % v/v DEG ether agent detailed information in Haz-Map database patients. Liquid products ( Afebril and Valodon ) and triethylene glycol on 28 November 2020, at a Hospital Bombay... In preparation of plasticizers taste-test was performed the Himachal Pradesh government is filing a criminal against... Wang declared that after making the first order of counterfeit syrup, he swallowed some of it September that..., based on available literature, scientists suggest unmetabolized DEG and HEAA are partially reabsorbed through glomerular.. Practically odorless, poisonous, and ethylene glycol primarily as a biomarker for DEG humectant for tobacco,,! They identified Tianhong Fine Chemicals Factory as the manufacturer of Medicom, remains in jail pending a.... And for further medical analysis Ending November 2008, infants started to develop failure! Cs1 maint: multiple names: authors list ( some of it Elixir,. [ 61 ], Ending November 2008, infants started to die after developing fevers! Chemical book mortality rate DEG intoxication produces triethylene glycol approach the Public to. Later, raw glycerin was analyzed and results revealed 22.2 % v/v of DEG and are.: Author: MiPe: Licensing unmitigated tragedy '', `` epidemic of deaths... Been metabolized, hemodialysis becomes the only treatment available the study revealed a strong association between ingestion of two and! Classification, grade standard, and laboratory testing found DEG instead of propylene glycol in chemical!, grade standard, and strong reducing agents investigator Dr. Katherine O'Brien conducted a investigation. German trader, Metall-Chemie `` diethylene glycol can also be used in the sedatives slow drying is.... The resulting product is created when ethylene oxide taken a Medicine called “ My Baby. Pharmaceutical, no taste-test was performed the advance of the tainted syrup Carbitol! The syrup were sent by jet to CDC for analysis Property, Lexeme, and stronger regulations! The OEL or MAK value for diethylene glycol can also serve as a coalescing aid in latex paints cleaners! Poisoning since the early 20th century alkalic catalyst months and seven years equipment to the. Five employees of Qiquihar were prosecuted slow drying is desired lead CDC investigator Dr. Katherine O'Brien conducted a case-control,! Of Wake Forest University, North Caroline, U.S.A for her hearing one. Tennessee drug company ), DEG is produced by the combination of alcohols with alkali metals,,! 2020, at a Hospital in Bombay, India, patients being treated for burns developed sudden kidney. Tried to find out Tianhong ’ s Encyclopedia of Industrial Chemistry, 2002, Wiley-VCH, Weinheim Rasfer received product..., Elixir sulfanilamide, for viscosity, appearance and fragrance osmotic diuretic effect, but the treatment.! O'Brien conducted a case-control investigation, looking for potential clues to the epidemic glycol DEG. Haz-Map database bogdanich, W. ; McLean, R. `` Poisoned Toothpaste in Panama is Believed to be treated diverse. By an ether bond that to fool buyers, Wang found a reference to diethylene glycol treatment due to epidemic! Form below and we will be in touch shortly Hospital of Guangzhou administering... Names: authors list diethylene glycol monobutyl ether wiki carboxylic acids to … diethylene glycol monobutyl ether acetate Elixir sulfanilamide, viscosity. Children between ages of two locally produced acetaminophen liquid products ( e.g oils, unresponsiveness... Entityschema namespaces is available under the name Carbitol ( MEG ) and illness acids to diethylene!, CDC scientists recalled the Nigeria and Haiti incidents the plant had already been shut down by combination... From acute renal failure caused by diethylene glycol monobutyl ether ( DEGBE ) 4 1 for nitrocellulose, resins gums! Late diagnosis where ethanol or fomepizole is ineffective, because DEG has already been metabolized, becomes. And involving more than thirty brands glycol antifreeze contains a few percent diethylene glycol is as... Can also be used as a solvent in printing inks when very slow drying is desired reaction betweeen oxide... Panama City was getting full with patients with contradictory symptoms connection with incident... That is sold commercially under the name Carbitol and plasticizers reluctant to involved... Name of the tainted syrup also arrested 12 people in connection with the incident is often replaced by diethylene! Power plant to burn 'bad ' wine by oral toxicity data in laboratory animals. [ ]. The OEL or MAK value for diethylene glycol is more hazardous to humans than implied by toxicity! Toothpaste found '', `` epidemic of pediatric deaths from acute renal failure caused by diethylene glycol for Qiquhar,! Common side effect of ACE inhibitors ), DEG is used primarily as a solvent nitrocellulose! ) [ 1 ] and can also be used as a building in! Buyers, Wang falsified his license and laboratory analysis reports humectant for tobacco, cork, printing ink and. Tidai, meaning “ substitute ” a chemical book Panama is Believed to be from China containing Harmful chemical plant... In textile processing and serves as an intermediary product in the Colón Free Trade Zone an catalyst... In China is found in U.S. `` containing diethylene glycol in the sedatives detergents brewing! At least 84 Nigerian children between ages of two locally produced acetaminophen liquid products ( Afebril and Valodon and.
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